In conclusion, EDA-A2, FGF-6, Dkk-4, IL-1 F9, Galectin-3, Layilin, bIG-H3, CHI3L1, ULBP-2, Gas-1, IGFBG-5, and FGF-9 were differentially expressed in patients with DVT compared to those in the NDVT and NC groups. The gene discussed is CHI3L1; the disease is deep vein thrombosis.