We thus hypothesised that somatic CpG hypermutation might accelerate tumour evolution due to failure to maintain methylated CpG sites in TP53. To this end, we analysed the sequence context of 39,925 somatic TP53 mutations from the GENIE database (R9, Jan 2021) (Bouaoun et al, 2016). This evidence concerns the gene TP53 and neoplasm.