GSDMD and polycystic ovary syndrome: More specifically, cyproterone acetate leads to decreases in the protein levels of NLRP3, GSDMD, GSDMD-NT, caspase 1 and cleaved-caspase 1 in GCs from mice with hyperandrogen-induced PCOS, in addition to decreases in IL-18 and IL-1β concentration in serum [150].