CASP1 and polycystic ovary syndrome: BSHLD administration significantly reverses IL-1β and IL-18 production in ovarian tissues of PCOS rats, in parallel to decreases in NLRP3, ASC, and caspase 1 mRNA levels and in NLRP3 protein levels, pointing the potential of Chinese herbal medicine BSHLD as an alternative for the treatment of PCOS, by limiting pyroptotic cell death of GCs.