Mechanistically, in in vitro PCOS models, HDAC1 inhibits lncRNA H19 transcription through H3K9 deacetylation on H19 promoter, and reduces the binding of H19 to miR-29a-3p to inhibit NLRP3 expression, thus suppressing GC pyroptosis [26]. The gene discussed is H19; the disease is polycystic ovary syndrome.