BSHLD administration significantly reverses IL-1β and IL-18 production in ovarian tissues of PCOS rats, in parallel to decreases in NLRP3, ASC, and caspase 1 mRNA levels and in NLRP3 protein levels, pointing the potential of Chinese herbal medicine BSHLD as an alternative for the treatment of PCOS, by limiting pyroptotic cell death of GCs. Here, IL18 is linked to polycystic ovary syndrome.