It thus decreases the cleavage of both caspase-1 (resulting in the suppression of caspase-1 activation) and GSDMD (resulting in the supression of pyroptosis), and the release of IL-1β, IL-18 and LDH in GCs, which are all normally increased in the case of PCOS. The gene discussed is GSDMD; the disease is polycystic ovary syndrome.