TNF and polycystic ovary syndrome: HDAC1 is also negatively correlated with the levels of certain inflammation markers (IL-6, IL-1β, IL-18, and TNF-α) in the serum of PCOS patients, among which IL-1β and IL-18 are mostly released from cells during pyroptosis, suggesting the association between HDAC1 and pyroptotic cell death in PCOS patients, and anti-pyroptotic function of HDAC1 via H19/miR-29a-3p/NLRP3 axis [23].