CD27 and congenital secretory chloride diarrhea 1: Among B cells, there was a higher frequency of exhausted subsets (IGD- CD27-, p = 0.030) and plasma blasts (CD24low CD38high, p < 0.0001) but lower proportions of classical switched memory B cells (IGD-CD27+, p = 0.0055) and memory B cells (CD24high CD38-, p < 0.0001) in the CLD cohort (Table 2).