RDX and neoplasm: Our study uncovered a surprising finding: ezrin, radixin and moesin appear to be dispensable for key aspects of macrophage behavior, involving actin cortex remodeling, such as the formation of lamellipodia and filopodia, the dynamics of membrane ruffles and podosomes, phagocytosis, migration in vitro (in 2D or 3D matrices) and ex vivo (into dermis or tumor tissues) as well as for the in vivo adhesion of macrophage precursors to activated vascular endothelium.