Importantly, for this smaller cohort consisting of 14 AML samples, the BCL2 SMPC and PBA profiling essentially maintained the performance parameters examined, including correlation, MSE and AUC from the ROC analysis, which were superior to those determined for the BH3 profiling (Extended Data Fig. 9d–g and Supplementary Table 5). Here, BCL2 is linked to acute myeloid leukemia.