Group 3 MB and retinoblastoma (Fig. 7a,b and Supplementary Table 14), along with the normal cerebellum and retina (Fig. 7c,d and Supplementary Table 14)—both of which are known to express high levels of OTX2—exhibited unique PPHLN1 and MADD splicing patterns. Here, MADD is linked to retinoblastoma.