Concerning their anti-apoptotic effects, MSCs-derived exosomes inhibited apoptosis of NRK-52E cells induced by cisplatin via activation of the ERK1/2 pathway according to12,94 have also recently illustrated their role in prohibiting CKD by interfering with fibrosis and apoptosis by transferring miRNAs (e.g., miR-199a-3p44 and miR-424-5p81). This evidence concerns the gene MAPK3 and chronic kidney disease.