We also found another hitherto unknown regulatory hub that is enriched for H3K27ac and H3K4Me3 (highlighted in orange) upstream of PCDHA. This hub has predicted regulatory associations with genes from all three clusters of the Protocadherin family, PCDHA, PCDHB and PCDHG, and the region has been characterized as a schizophrenia risk locus that is linked with the regulation of all three protocadherin families in the context of brain41. This evidence concerns the gene PCDH11X and schizophrenia.