SPTLC2 and neoplasm: Sptlc2Flox/FloxCD11c-cre mice, which had dendritic cell-specific Sptlc2 deficiency, grew tumors of similar size, and the tumor weights did not significantly differ from those in wildtype littermates (Supplementary Fig. 7g), thus suggesting that the enhanced tumor growth observed in Sptlc2Flox/FloxLyz2-cre mice was not due to nonspecific deletion of Sptlc2 in dendritic cells.