Lending further support to the clinical significance of enhanced MitoS activity linked to valine catabolism, propionyl-CoA carboxylase (PCCA), succinyl-CoA ligase subunit beta (SUCLG2) and succinate dehydrogenase subunit C (SDHC) were all determined to be within the top 20 most correlated genes in relation to HIBCH expression in a cohort of patients (TCGA-PRAD) with prostate adenocarcinoma (Supplementary Table 3). This evidence concerns the gene PCCA and prostate adenocarcinoma.