HIBCH and posterior cortical atrophy: Inhibition of valine catabolism via the suppression of HIBCH, a key enzyme facilitating the conversion of 3HIB-CoA to 3HIB, results in metabolic catastrophe for PCa cells, including reduced intracellular succinate among other TCA metabolites, reduced oxidative and glycolytic function, induction of mitochondrial fragmentation and reduced cell growth and viability.