CDH2 and neoplasm: According to our RNA-seq data, in addition to CDH1/CDH2 (E-cadherin/N-cadherin), ICAM1 was upregulated in both T1M1 PDAC tissues and MET-containing CM-treated PDAC cells, which indicated that METs may affect tumour cell adhesion through ICAM1 (Fig. 7e, Fig. 7k, Supplementary Fig. 10d).