Then we further identified cancer cells (aneuploid) according to copy number variation (CNV) analysis on those clusters (2, 4, 8, 10, 16, and 17) that exhibited significant enrichment in epithelial gene transcripts, including EHF, PIL5, CST3, TNC, LPLl, IL11, CADM1, COL18A1, GM6093, FST, GM49504, NEAT1 and TSC22D3 (Fig. 4d, e, Supplementary Fig. 5c, d). This evidence concerns the gene CADM1 and cancer.