Furthermore, we did not observe a similar MLKL expression pattern and RIPK3-independent necroptosis mode in pancreatic ductal epithelial cells (HPNE cell line), which further supported the specificity with which an aberrant elevation in MLKL mediates necroptosis in tumour cells rather than in pancreatic ductal epithelial cells (Supplementary Fig. 2c, Supplementary Fig. 3d). Here, MLKL is linked to neoplasm.