For better understanding of the molecular mechanisms that regulate the proliferation capability and tumorigenic activity of MM cells, we performed RNA-sequencing analyses using LILRB4-knockdown and scrambled MM cells (ARP-1, OPM-2 and LP-1 cells) and demonstrated that approximately 14 genes were markedly decreased upon LILRB4 knockdown, including CT45A10, EGR1, CEBPA-DT, STAB1, ATP9A, PTGS2, SERF1B, PFKFB1, PMS2P7, CEP17OP1, and MSC-AS1 (Fig. 4A). This evidence concerns the gene PFKFB1 and Miyoshi myopathy.