Herein, we showed that IKZF1 may enhance LILRB4 expression and promote MM progression via PFKFB1 pathway and blocking with LILRB4 antibody showed notable effect in suppression of MM cell growth, indicating the combined treatment with IKZF1 or LILRB4 inhibition may be a new way for MM treatment. Here, IKZF1 is linked to Miyoshi myopathy.