Then, quantitative RT‒PCR analysis was performed to examine the mRNA levels of candidate genes, including ALDH7A11, GADD45A, BCL2A1, IKZF2, IKZF3, and PFKFB1, which were significantly reduced in all three tested LILRB4-knockdown MM cell lines (ARP1, OPM2 and LP1 cells) (Fig. 4B). This evidence concerns the gene GADD45A and Miyoshi myopathy.