Nonetheless, we observed some indication of nominal significance with 1 or more folate variables being differentially associated with CRC according to somatic mutations in AXIN2, B2M, BCOR, CHD1, DOCK3, FBLN2, MAP3K21, POLD1, RYR1, TET2, UTP20, and ZNF521. The associations between folate and CRC were mostly inverse or toward the null, except for DOCK3-, CHD1-, and ZNF521-mutated tumors for which we observed positive associations. Here, MAP3K21 is linked to colorectal carcinoma.