Given the high degree of variation in frequency of YeiH-specific CD8+ T cells across individuals, this approach will likely need to be refined to more directly measure pathogenic CD8+ T cells and/or to account for biologic confounders, similar to the use of CRP levels to measure systemic autoimmunity after adjusting for obesity (48). The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.