CD28 and inflammatory bowel disease: We next examined YeiH.232-240 tetramer+ CD8+ T cells for surface expression of DEGs associated with the axSpA motif (Figure 3C) (KLRB1 [CD161], CCR6, CD28, and ITGAE [CD103]) as well as integrin α4β7 (lymphocyte Peyer’s patch adhesion molecule-1 [LPAM-1]), which is involved in trafficking to mucosal surfaces and is a therapeutic target in inflammatory bowel disease (34, 35).