Of the glial markers tested here (Cx43, ADK, P2X7, and GFAP) that have been reported to have altered expression levels in epileptic tissues, particularly in patients and animal models of temporal lobe epilepsy [reviewed in (Ahn et al., 2023; Aronica et al., 2013; Bedner & Steinhäuser, 2023; Hayatdavoudi et al., 2022)], we found that only the expression level of GFAP was altered in 2 months old ELS mice. This evidence concerns the gene P2RX7 and temporal lobe epilepsy.