The unaltered expression levels of ADK, Cx43, and P2X7 receptors which contribute to the development of epilepsy (Aronica et al., 2011; Henning et al., 2023; Pannasch et al., 2011; Skaper et al., 2010; Song et al., 2019; Wallraff et al., 2006) together with the finding that astrogliosis per se without overexpression of ADK is insufficient to trigger SRS (Li et al., 2008) are consistent with the lack of SRS in our ELS mice. The gene discussed is GJA1; the disease is epilepsy.