Among the most significant genes, a decrease in keratins in HGSIL compared with LGSIL stands out (Figure 4B) as well as the overexpression of members of the MAGE gene family of cancer/testis antigens in ASCC compared with HGSIL, like MAGEA4, MAGEA3, and MAGEA1 (Figure 4C). The gene discussed is MAGEA4; the disease is cancer.