In this context, tumors with moderate to high CD3 and CD8 expression were associated with lower tumor purity scores (P < 0.01) and higher cell fractions of CAFs (P < 0.05), macrophages (P < 0.05), and CD4+ T cells (P < 0.05) as revealed by EPIC analysis (Figure 7D). Here, CD8A is linked to neoplasm.