Proteins like Acca (acetyl-CoA carboxylase carboxyl transferase subunit alpha), glyA (glycine hydroxymethyltransferase), glyQ (glycyl-tRNA synthetase alpha chain), eno (enolase), pgk (phosphoglycerate kinase), and por (pyruvate-ferredoxin/flavodoxin oxidoreductase) were previously identified in anal samples from individuals with precancerous anal lesions (10), underlining their potential roles as metabolic markers in anal cancer progression. The gene discussed is SHMT2; the disease is anal carcinoma.