Similarly, HFD+CKD versus CKD upregulated 6 canonical inflammasome genes, including IL1B, ITPR2, MAVS, NAMPT, OAS2, and TXN2, and 4 noncanonical inflammasome genes, including IL1B, SLC25A22, GBP6, and GBP3 (Supplemental Figure 4C). Here, ITPR2 is linked to chronic kidney disease.