We found that WT HFD+CKD upregulated 21% of 165 ROS regulator genes; however, HFD+CKD CASP11–/– reduced the upregulation of ROS regulator genes to 3% (Figure 8A), suggesting that CASP11 plays significant roles in promoting the expression of ROS regulator genes in the HFD+CKD aorta. The gene discussed is ROS1; the disease is chronic kidney disease.