IL1B and chronic kidney disease: However, blood urea nitrogen (BUN) levels and IL1B levels in HFD+CKD were equivalent to those of ND-CKD, suggesting that kidney dysfunction was not further aggravated in the HFD+CKD group in the experimental setting (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.177229DS1).