ATF3 and fatty liver disease: In addition, we also analyzed expressions of 266 immunometabolism regulator genes in human IL1B-stimulated ECs (71) and found that immunometabolism transcription factor ATF3 was upregulated (Figure 9D), which was shown to interact with RGS7 and histone acetyltransferase Tip60 and form a unique pathway to promote hepatic steatosis (72), suggesting that IL1B promotes immunometabolism reprogramming, histone acetylation, and gene expression.