However, CASP11–/– decreased blood CD45+CD11b+ monocytes in HFD sham mice compared with WT HFD sham mice, and CASP11–/– did not significantly change blood CD45+CD11b+ monocytes or CD45+CD11b+F4/80+ macrophages in HFD+CKD mice (Figure 4, C and D), suggesting that HFD+CKD activates CASP11 and promotes monocyte and macrophage migration into the aorta rather than increasing the generation of monocytes and macrophages in the blood. The gene discussed is ITGAM; the disease is chronic kidney disease.