Our data show that HFD+CKD versus HFD upregulated 6 canonical inflammasome genes, including IL1B, ITPR2, CYBB, NAMPT, MAVS, and TXN2, and 3 noncanonical inflammasome genes, including IL1B, SCL25A22, and GBP6. Here, GBP6 is linked to chronic kidney disease.