The data show that WT CKD+HFD significantly increased chemokine CCL22 and CHI3L1 in the blood compared with WT sham-HFD, and CASP11 deficiency decreased 8 chemokines and cytokines in the blood: CCL21, CCL22, MMP-3, CHI3L1, IL12B, MPO, TNFRSF11B, and PCSK9. The gene discussed is MMP3; the disease is chronic kidney disease.