Current data show that SF-1 stimulates baseline expression of both GAD1 and-2 transcripts during euglycemia, yet imposes divergent control of GAD isoform mRNAs during hypoglycemia as SF-1 counteracts hypoglycemic inhibition of GAD1 transcription, yet is critical for down-regulated GAD2 gene profiles. This evidence concerns the gene GAD1 and Hypoglycemia.