In their research on the association between poor survival, therapy resistance in obese pancreatic cancer patients, and microbial metabolites, Kesh et al. (2022) focused on two microbial metabolites: Queuosine and S-adenosylmethionine (SAM).107 Queuosine, a bacterial t-RNA homolog, has been noted for its role in inhibiting cell proliferation and regulating metabolism.108 It is also linked to the induction of PRDX1, an antioxidant protein that protects tumor cells from chemotherapy induced oxidative stress107 (Figure 1g). This evidence concerns the gene PRDX1 and familial pancreatic carcinoma.