Pellegata (1994) suggested that the absence of functional p53 protein contributes to chemotherapy resistance.92 Kitazono et al. (2010) found that it can induce histone acetylation and the expression of the tumor-suppressor p53 in human pancreatic carcinoma cell lines lacking functional p5393 (Figure 1e). The gene discussed is TP53; the disease is exocrine pancreatic carcinoma.