HIF1A and neoplasm: During malignant progression, angiogenesis is a crucial process facilitating ecosystem maintenance and tumor metastasis.[18] The ECM plays critical roles in angiogenesis by secreting proangiogenic growth factors and stabilizing vascular tissues.[19] Hypoxia‐inducible factor‐1α (HIF‐1α), a transcription factor, promotes the transcription of proangiogenic genes, such as vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors (VEGFR).