PDX and organoid models reproduce the genetic and phenotypic heterogeneity of the original tumors and mimic the biological characteristics much better than in vitro culture models.[54] Therefore, we established PDX and organoid models of GC, as we have previously described, and tested the effect of pharmacological inhibition of DDR1 with 7rh benzamide.[55] Treatment with 7rh benzamide efficiently inhibited tumor angiogenesis and growth in the PDX models. This evidence concerns the gene DDR1 and gastric cancer.