In addition to angiogenesis, some studies have demonstrated that DDR1 enhances metastatic capacity, but the mechanism is not well understood.[45] Actin cytoskeleton reorganization is closely related to tumor cell migration, and DDR1 is suggested to be correlated with actin cytoskeleton remodeling, although it plays distinct roles in different cell types.[28, 29, 46] Some studies have demonstrated that DDR1 stimulates the formation of linear invadosomes and actin stress fibers in breast cancer cells,[28, 30] while Yeh et al. Here, DDR1 is linked to breast carcinoma.