As a consequence, when evaluating the biological relevance of CD4+ T cell-targeted RACK1 deficiency in host resistance to P. yoelii 17XNL infection, we noted that coinciding with the steadily ascending parasite-specific IgG, WT mice developed a peak parasitemia (~28.95%) at day 17 p.i., the parasite burdens were gradually declined afterward, and 100% of mice were fully recovered from the infection within 30 days. This evidence concerns the gene CD4 and infection.