In this study, we identified the top-ranked 11 genes (STAT1, TLR4, CXCL10, CCL2, JUN, DDX58, IRF7, ICAM1, MX2, IRF9, and ISG15) as the hub of the shared differentially expressed genes (hub-sDEGs) highlighting their molecular mechanisms for which SARS-CoV-2 infections and different lung diseases stimulate each other. This evidence concerns the gene TLR4 and lung disorder.