The interaction network analysis of hub-sDEGs with different diseases from independent databases showed that some of our proposed hub-sDEGs (CCL2, STAT1, MX2, ICAM1, JUN, and IRF7) are significantly associated with different lung diseases including asthma, bronchiectasis, pneumonia, pulmonary fibrosis, tuberculosis, lung injury, lung neoplasms (Fig 3 and S3 Table). The gene discussed is MX2; the disease is bronchiectasis.