Moving forward to SHANK3 which is a postsynaptic scaffolding protein involved in the organization and function of synapses [43], a mutation in SHANK3 have been primarily associated with Phelan-McDermid syndrome, similarly in our patient, the syndrome is characterized with a neurodevelopmental disorder characterized by intellectual disability, autism spectrum disorder, and seizures [44]. This evidence concerns the gene PROS1 and Monosomy 22q13.