IL4 and tuberculosis: The rabbit model has been relevant to study the immunopathogenesis produced by M. tuberculosis or M. bovis infection because it shows similar characteristics to human TB disease, such as pulmonary necrosis with cavitation [99–101], which was associated with delayed and suboptimal macrophage activation, delayed differentiation, and accumulation of antigen-specific T cells with upregulated networks of IL-4 and B-cell activation [98].