Indeed, IL-17A, in synchrony with TNF-α, is reported to induce the secretion of chemokines and cytokines such as IL-6 and IL-23 in endothelial cells associated with neutrophil recruitment [82, 83], which also has been related to the promotion of granuloma formation, not only in M. tuberculosis infection but also in experimental paracoccidioidomycosis [84, 85]. This evidence concerns the gene TNF and Granuloma.