SCRIPro could accurately predicts well-known master regulators including SPI1, IRF1, FLI1, and STAT2 for mono/macrophages, GATA3, RUNX3, SMARCA4, JUND, and MYB for T-cells, PAX5, BCL2, and IRF4 for B and tumor B-cells (Fig. 3b, Supplementary Fig. S3b). This evidence concerns the gene SPI1 and neoplasm.