CAPItello-281 (Capivasertib Plus Abiraterone as Treatment for Patients With mHSPC and PTEN Deficiency)40 also compares capivasertib (an AKT inhibitor) with abiraterone vs abiraterone in patients with PTEN deficiency receiving androgen deprivation therapy in the mHSPC de novo setting. The gene discussed is AKT1; the disease is hyperinsulinemic hypoglycemia, familial, 4.