We reanalysed Njunge et al. proteomic data [33] and observed that in addition to APOE, the CSF levels of APP and other AD-related proteins such as NPTX1, PRNP, NCAM1, SPARC, AGT and IGF2 were also significantly elevated in CM compared to ABM (Fig. 1A, B; Supplementary File Table 1). Here, APP is linked to Alzheimer disease.