The expression of PD-1 and PD-L1 was significantly downregulated in human PBMCs, T cells, and myeloid dendritic cells in patients with coronary artery disease compared to healthy controls, and reduced levels of PD-1 and PD-L1 were associated with an increased burden of coronary atherosclerotic plaques [68]. Here, CD274 is linked to coronary artery disorder.