Moreover, mice with experimental autoimmune myocarditis (EAM) induced before anti-PD-1 treatment showed a higher grade of myocardial inflammation, while concomitant induction of EAM and administration of anti-PD-1 antibodies did not result in exacerbated myocarditis, suggesting that prior autoimmune factors might play a role in triggering ICI-induced myocarditis [113]. This evidence concerns the gene PDCD1 and myocarditis.