Based on the IHC staining of LZTS1 in a tissue microarray with 90 cases of CRC and paired adjacent colorectal tissues (Figure 4A), we found that the protein expression of LZTS1 was significantly upregulated (p < 0.01) in CRC tissues compared to adjacent colorectal tissues (Figure 4B), consistent with the high expression of LZTS1 in CRC tissues from TCGA and GEO datasets. This evidence concerns the gene LZTS1 and colorectal carcinoma.