Other studies provided evidence that sEVs released by acidic tumor cells contain high levels of tumor-associated molecules, that they can transfer to tumor cells that do not express these molecules, such as caveolin-1 [159] and mir-214 [165] in melanoma cells, carbonic anhydrase (CA) IX in prostate cancer cells [166], miR-21 and miR-10b in hepatocellular carcinoma cells [167]. This evidence concerns the gene CA9 and neoplasm.