TGFB1 and neoplasm: The same effect on macrophages polarization was described by Park et al. [123], who observed that sEVs produced by hypoxic tumor cells are highly enriched in immunomodulatory proteins and chemokines such as CSF-1, CCL2, FTH, FTL, and TGFβ, while Qian et al. [124] and Xu et al. [125] found that hypoxic glioma-derived sEVs markedly induce M2 macrophage polarization through miR-1246 and miR155-3p.