HIF1A and familial pancreatic carcinoma: Zeng et al. recently described a hypoxic vesicular circular RNA (circRNA)-mediated mechanism of conferred resistance in pancreatic cancer (PC) cells: CircZNF91, overexpressed in hypoxic sEVs, can be transmitted to normoxic pancreatic cancer cells, enhancing the stability of HIF1α and leading to chemoresistance of normoxic pancreatic cancer cells [89].