MAP2K7 and cancer: While MAPK signaling in cancer is universally known for its role in proliferation (Downward, 2003), and MEK inhibitors are used to block proliferation (Barbosa et al., 2021; Flaherty et al., 2012), it is noteworthy that Netrin stimulation of MAPK signaling is reported to provide survival signals and to guide axon outgrowth in a non-proliferative context (Forcet et al., 2002; Chen et al., 2017a).