However, the expression of activated B cells, activated CD4 T cells, activated CD8 T cells, CD56bright natural killer cells, CD56dim natural killer cells, central memory CD4 T cells, central memory CD8 T cells, effector memory CD4 T cells, eosinophils, immature B cells, memory B cells, natural killer cells, natural killer T cells, plasmacytoid dendritic cells, T follicular helper cells, and type 1 T helper cells in the tuberculosis group were significantly lower than those in the control group. The gene discussed is CD4; the disease is tuberculosis.