GPR177 belongs to the highly conserved GPCR protein family, several members of which are methylated by m6A and are involved in disease progression, for example, m6A methylated GPR133 was found to promote lung adenocarcinoma cell proliferation and tumor growth,44 while METTL3 was reported to promote m6A modification of GPR166 to stimulate defensin expression, thereby impeding Escherichia coli infection.45 The gene discussed is ADGRD1; the disease is lung adenocarcinoma.