In fact, it has been proven that the upregulation of PI3K‐AKT‐mTOR signaling is associated with the endocrine resistance of breast cancer.[3, 27] Consistently, deficiency of STING signaling in parental MCF7 and ZR75.1 cells enhanced the phosphorylation of AKT1 and GSK3β (Figure 6C), indicating activation of PI3K‐AKT signaling. This evidence concerns the gene STING1 and breast cancer.