IFNA1 and neoplasm: Cytosolic DNA activates the cGAS‐STING pathway to induce IFN‐JAK/STAT‐dependent cell death.[24] First, we observed that the expression level of p‐STAT1 in MCF7/ZR75.1 cells was significantly higher than that in R‐MCF7/R‐ZR75.1 cells when tumor cells were transfected with HT‐DNA (Figure 3A).