In line with the TCGA, GSE164158, GSE45670, and the Cancer Cell Line Encyclopedia (CCLE) data (Figure S1, Supporting Information), TDP‐43 showed increased expression in cancerous tissues in comparation with normal tissues in other ESCC cohorts (GSE38129, GSE77861, and GSE32424) (all P < 0.05) (Figure 1C–E). Here, TARDBP is linked to esophageal squamous cell carcinoma.