TF and adenocarcinoma: For ESCC, the genomic analyses revealed that TP63 is frequently amplified in cancerous tissues and is significantly up‐regulated in comparison with non‐tumor and adenocarcinoma tissues.[42] For example, TP63 can bind to promoters of DKK3, LINC01503 and/or RSK4 to drive high expression of these oncogenes in ESCC.[23, 43, 44] In line with these, we found that TP63 could transcriptionally enhance TDP‐43 expression and, thus, promote ESCC progression, which broadens the understanding of mechanisms by which the master TF TP63 functions.