PABPC1, a highly conserved RBP in species ranging from yeast to human, locates dominantly in cytoplasm, coats the 3′ end of cytoplasmic mRNAs with very high affinity, packages the mRNAs into poly(A) RNPs, physically protects the transcripts from unspecific degradation.[47, 48] It has been reported that PABPC1 could promote ESCC progression through stabilizing IFI27 mRNAs.[49] Importantly, we found that TDP‐43 and PABPC1 interacted in ESCC cells, which improved PABPC1 binding to TP63 mRNAs, increased TP63 expression, and contributed to esophageal tumorigenesis. This evidence concerns the gene TARDBP and esophageal squamous cell carcinoma.