It has been shown that the promoter activities of the pGL3‐TP63‐WT construct with the TP63 promoter containing the TDP‐43 binding motif were significantly higher than those of the pGL3‐TP63‐del construct without the TF TDP‐43 binding motif in ESCC cells (Figure 4G–H). This evidence concerns the gene TF and esophageal squamous cell carcinoma.