TARDBP and esophageal squamous cell carcinoma: RBPs are a class of highly conserved proteins that regulates RNA stability, RNA splicing, RNA alternative polyadenylation, and RNA transport during tumorigenesis.[7, 32, 33, 34] In the current study, we found that RBP TDP‐43 was highly expressed in ESCC and associated with poor prognosis of patients.