We found that the TDP‐43‐KD KYSE‐450 or KYSE‐510 cells showed inhibited proliferation ability in comparation with controls (all P < 0.001) (Figure 2C), whereas the TDP‐43‐OE ESCC cells exhibited increased proliferation capability compared to control cells (both P < 0.01) (Figure 2D). Here, TARDBP is linked to esophageal squamous cell carcinoma.