Among these thirteen genes, three genes (TP63, DHX9, and TBL1XR1) showed remarkably higher expression in ESCC tissues than that in normal tissues from the TCGA, GSE164158, or GSE45670 cohorts (all P < 0.05) (Figure 3A). The gene discussed is TBL1XR1; the disease is esophageal squamous cell carcinoma.