For ESCC, the genomic analyses revealed that TP63 is frequently amplified in cancerous tissues and is significantly up‐regulated in comparison with non‐tumor and adenocarcinoma tissues.[42] For example, TP63 can bind to promoters of DKK3, LINC01503 and/or RSK4 to drive high expression of these oncogenes in ESCC.[23, 43, 44] In line with these, we found that TP63 could transcriptionally enhance TDP‐43 expression and, thus, promote ESCC progression, which broadens the understanding of mechanisms by which the master TF TP63 functions. The gene discussed is DKK3; the disease is esophageal squamous cell carcinoma.