NLRP3 and metabolic dysfunction-associated steatotic liver disease: In the pathogenesis of NAFLD, the activation of NLRP3 inflammasome in the second step can be triggered by various intracellular signals, including extracellular ATP, cholesterol crystals, P2X purinergic receptor 7, mitochondrial ROS, mitochondrial DNA (mtDNA), uric acid, cardiolipin, perfluorooctanoic acid (PFOA), endoplasmic reticulum (ER) stress, and impaired mitochondrial autophagy.