In summary, the pivotal molecular players implicated in pyroptosis, such as the NLRP3 inflammasome, GSDMD, and caspases, exert a critical influence on the initiation and advancement of NAFLD by contributing to pyroptosis and associated inflammatory reactions within hepatocytes, Kupffer cells, and hepatic stellate cells. Here, GSDMD is linked to metabolic dysfunction-associated steatotic liver disease.