Several conflicting data portrayed ANGPTL4 either as a protumorigenic or proangiogenic molecule [44,45] or as a primarily antiangiogenic and antitumorigenic cytokine [46,47], and recent preclinical reports supported the roles of cANGPTL4 in suppressing tumor growth and angiogenesis and nANGPTL4 in inhibiting angiogenesis and tumor metastasis [18], indicating that the C-terminal and N- terminal fragments of ANGPTL4 could have opposing functions during tumor progression. The gene discussed is ANGPTL4; the disease is neoplasm.