ANGPTL4 and gastritis: Collectively, our data identify ANGPTL4 as a novel pathological host factor that contributes to gastritis as well as promotes H. pylori colonization, mostly acting through 2-pronged mechanisms, involving both suppressing gastric neutrophil infiltration and promoting Treg chemotaxis/proliferation, which reshapes host gastric environments with features of infiltration of mononuclear cells more than granulocytes.