For example, C5 is required for the process of remyelination in chronic lesions of mice in a mouse experimental autoimmune encephalomyelitis (EAE) model, as C5-deficient animals display high gliosis and extensive lesional scarring in combination with reduced axon survival and remyelination when compared to C5-sufficent animals (129). The gene discussed is C5; the disease is experimental autoimmune encephalomyelitis.