In HCC, lncRNA ICR upregulates ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation [52]; in GC, lncRNA MACC1-AS1 promotes the stability of MACC1 mRNA by physically binding to MACC1 mRNA [53]; In glioma, lncRNA PTB-AS could directly bind to the 3′ UTR region of PTBP1 mRNA, which masks the binding site of miR-9 in the PTBP1, resulting in the inability of miR-9 to recognize PTBP1, thus enhancing the stability of PTBP1 [54]. The gene discussed is PTBP1; the disease is glioma.