LncRNA CACClnc plays an important role in CRC chemoresistance, and it was found that lncRNA CACClnc specifically binds to YB1 and U2AF65 (a subunit of the U2AF splicing factor) and promotes the YB1 and U2AF65 interaction, which in turn regulates the AS process of RAD51 mRNA [83]. Here, U2AF2 is linked to colorectal carcinoma.