SMAD4 and neoplasm: LncRNA Smyca is also one of the targets for overcoming tumor chemoresistance, and lncRNA Smyca enhances the TGF-β/Smad signaling pathway by acting as a scaffold that promotes Smad3/Smad4 binding, and further serves as a Smad target to amplify the TGF-β signaling pathway thereby promoting tumor progression [84].