Furthermore, shRNA against lncRNA SRA suppressed the production of proinflammatory cytokines (such as TNF-α, IL-1β, and IL-6), as well as the translocation of NF-κB into the nucleus in both PCOS mouse ovaries and primary GCs treated with dehydroepiandrosterone sulfate (DHEA) [57]. This evidence concerns the gene IL6 and polycystic ovary syndrome.