Therefore, to determine if alterations to the crosstalk between miRNAs and the PI3K/Akt pathway were mediating the beneficial effects of FhHDM-1, expression profiles for both miRNAs and mRNA were determined from β-cells, which were exposed to the proinflammatory cytokines that drive T1D pathogenesis in the presence and absence of FhHDM-1. This evidence concerns the gene AKT1 and type 1 diabetes mellitus.