Tejada Neyra et al. demonstrated that IDH-mutated gliomas tend to cluster around the rostral extension of the lateral ventricles, utilizing voxel-based lesion-symptom mapping.7 Similarly, Ellingson et al. identified that EGFR-amplified tumors predominantly occur in the left temporal lobe, whereas tumors without PTEN loss are mostly located in the frontal lobe.10 These findings underscore the importance of considering the spatial distribution of molecular subtypes in GBs. Here, PTEN is linked to central nervous system cancer.