in 2008 defined cachexia as weight loss greater than 5% over the prior 12 months in the presence of cancer and three associated conditions: decreased muscle strength, fatigue, anorexia, low fat-free mass, or abnormal biomarkers (albumin, C-reactive protein, total protein, white blood cell, hemoglobin, and transferrin) (11). The gene discussed is CRP; the disease is Cachexia.