Genetic evidence of lipid metabolism involvement in AMD is supported by polymorphisms in multiple genes such as apolipoprotein E (ApoE), hepatic lipase (LIPC), cholesterol ester transfer protein (CETP), lipoprotein lipase (LPL) and ATP binding cassette subfamily A member 1 (ABCA1), all being identified as risk factors for development of AMD [17-19,22,35]. Two genome-wide association studies (GWAS) have linked AMD to variants in the hepatic lipase (LIPC), cholesterol ester transfer protein (CETP), ATP-binding cassette subfamily A member 1 (ABCA1), and lipoprotein lipase (LPL) genes [36-38]. Here, APOE is linked to age-related macular degeneration.