Due to clinical similarities and overlaps in immunohistochemistry, including CD34 positivity, DFSPs must be differentiated from other benign and malignant lesions including, but not limited to, dermatofibromas, schwannomas, cutaneous neurofibromas, and solitary fibrous tumors (Table 1) [2]. This evidence concerns the gene CD34 and cutaneous fibrous histiocytoma.