TRPV1 and irritable bowel syndrome: The roleof TRPV1 has been repeatedly investigated in animal modelsof colitis, and despite several studies, its role in protecting orinducing intestinal inflammation is still controversial.51 It can be attributed to the different phenotypesand phases of IBD, the involvement of TRPVs in cell signaling pathways,the immune environment, and the limitations of experimental approaches.51 Although some studies show TRPV1 activationin UC, in our experimental model, this increase was not statisticallysignificant compared with the control mice.