CHDH and coronary artery disorder: Finally, this investigationof the transporter substrate- and inhibitor-specificproperties of CHD and CDCHD helps explaining the distinct PK profilesobserved for CHD compared to CDCHD, in particular with respect toplasma and urine concentrations.29 In particular,the observation of an accumulation potential of CHD and CDCHD in theproximal tubule cells warrants the assessment of the nephrotoxic potentialat different doses of CHD and CDCHD before further preclinical development.