• FT4 6.9 pmol/L (reference range: 10.5–24.5), TSH 0.1 mU/L (0.27–4.2), cortisol 57 nmol/L (133–537), testosterone <0.5 nmol/L (6.7–25.7), LH <1.0 U/L (1.7–8.6).• MRI: pituitary macroadenoma with recent hemorrhage. The gene discussed is PLOD1; the disease is hemorrhage.