SIRT1 and Cognitive impairment: In recent studies on vascular dementia treatment, ligustilide has been shown to activate the AMPK/SIRT1 signaling pathway, ameliorate pathological changes in the hippocampus cells of dementia rats, promote remyelination, suppress the expression of inflammatory factors, and alleviate cognitive impairment following cerebral hemorrhage (Peng et al., 2022).